There is no real one right way. I changed my setup about 4 to 5 times before i got the current setup. I have the MPC 2000/M-audio axium 25/M-audio Project mix and Pro tools M-powered/reason and some other stuff but i used to have the MPC as the master because i used it a lot. But now i have Pro-tools as the master. You gotta take all that in consideration as well as the space your working with.