It depends on the program and how much change you wish to apply (some can leave audible artifacts). Are you singing? If so, it might be necessary, but for rapping, I wouldn’t see why it woud be important...
Find the setting you like and change every key/pitch-based track you have (for example keys, bass, guitar, and/or horns and strings) by exactly the same amount. No need to tweak drums or percussion, unless you are going for a specific in-tune effect.
GJ
Gregg Juke
Nocturnal Productions
The Sonic Vault Recording Studio
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