Hi Chris,
It looks like your audio driver got shut off, this happens to me if I shut my macbook or change my driver in something like Pro Tools or another DAW.
You just need to turn your audio driver back on. I run OS X but it should be more or less the same.
Go to Reason's Preferences.
Click "Audio" in the drop down menu
There should be another drop down menu on the Audio Preferences page you should be looking at with the list of possible Audio Drivers, just change it to the appropriate one.
Hope it helps.