I dont do it much, because like everyone said it's hard...but I strive to layer 4-5 samples on a track...thats where you get that freshness

and yes, i do samples horns and strings and sounds and save them on my MPC and try to use them later when I get new main samples i think theyll fit with...but i usually end up making full projects and scrapping them cause it just isnt right, I need a 10band EQ