when u shift the pitch for one thing everything will sound wrong
a friend of mine in a band finds that getting his piano tuned is expensive, so they tune tune all the other instruments around it...do the same.
after pitch shifting...do not use the root 'C5" key..instead try the black ones like C# and D# and the same usually applies with other instruments
If after pitch shifting, you alternate note fine pitches (as in the piano roll), u can use C as your root note, but will have to harmonize (apply the same alternations to the note fine pitch)