It depends.
When I sample, I try to go for the feel as if it were being played live, so i like realistic drums and patterns, but some producers like Alchemist or Heatmakerz just go for whats knockin'. Though they use realistic drums and its jammin all the same, if you listen to alot of the rhythm of they use for their drums, kicks, and hats, its usually something a live band would never do. Just choose your own preference.