You can make a sample "your own" or unique many ways...
The sample choice itself.
EQing.
Effects you put on it.
The way you chop it.
The way you arrange it.
Just experiment. Get creative/crazy with it.
thats the fun part. but nobody can really tell you how to do that other than chop it up. cut the sample up and rearrange it into what you want it to beon just one sample thought, how can i can make it sound different from the original