Dr. Dre has made a career outta having musicians just replay a dam sample exactly how it's heard on the record, but with elements removed and separated. When you listen to songs like Lil Ghetto Boy, It's Funky Enough, Firm Fiasco and California Love remix it's an example of how to get better separation out of a sample, by taking out a part you don't want and just having each instrument replayed and re-composed. Just listen to Foster Sylver's Misdemeanor, it's a good example.
I heard Hank Shocklee speak in an interview about the sound design capabilities of DAWs today, he explained that you can re-create almost anything as long as you understand the aspects of how the original sample was recorded. If you go into the virtual instruments and plug ins, many of the instruments and effects are there as software emulations for you to use such as Moog and Rhodes keyboards. It depends on the ear behind the software and music to re-create the sample accurately enough.