Of course. Especially Logic. Logic has an amazing assortment of instruments, fx, presets, etc, etc. And with all of that, Logic is amazingly efficient. Reason is basically a rack of synths, sampler, etc, with a really basic sequencer tacked on. It lacks all the audio recording, editing, mangling features common in other programs. So, the easiest way to look at Reason is as, "some extra synths for your sequencer". You connect them via Rewire. But if you have a sequencer that already has all of that stuff, (Logic has it in abundance) then the only reason to use Reason would be maybe if there's something particular in Reason that you can't find anywhere else. One such thing that people commonly talk about as being very unique is the Scream distortion effect in Reason. I also agree that it is unique among software distortion effects. Of course, each sequencer has a range of unique features not found elsewhere, and Reason has other features that are cool. But to kind of condense the whole thing down, the best "all in one" in my opinion is Logic. Now, I'm a Cubase guy. I find Logic to be too illogical for my tastes. I actually do own Logic Studio 8. But Cubase does it for me. It is not very good about providing great instruments but I like the sequencing and the logic matches my own way of thinking. But you do need to bring your own instruments. But I would absolutely love to have all of Logic's content inside Cubase.